Researchers from Duke-NUS Medical School (Duke-NUS), in collaboration with the Agency for Science, Technology and Research (A*STAR)’s Bioinformatics Institute (BII), and the University of Texas Medical Branch (UTMB), U.S., have discovered that the dengue virus changes its shape through mutations.

According to several articles:

Science News: Dengue virus becoming resistant to vaccines and therapeutics due to mutations in specific protein

The Economic Times: Dengue virus is becoming resistant to vaccines and treatment: Study

Medical Xpres:  Dengue virus becoming resistant to vaccines and therapeutics due to mutations in specific protein